2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19383
    Ertiprotafib 251303-04-5 98.86%
    Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ.
    Ertiprotafib
  • HY-19480
    Ulodesine 548486-59-5 ≥99.0%
    Ulodesine is a purine nucleoside phosphorylase (PNP) inhibitor. Ulodesine inhibits PNP with IC50 value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia.
    Ulodesine
  • HY-21088
    3-Amino-2-piperidinone 1892-22-4
    3-amino-2-piperidinone is a cyclic ornithine analogue. 3-amino-2-piperidinone can be used to synthesize N-(2-oxopiperidin-3-yl)dodecanamide. N-(2-oxopiperidin-3-yl)dodecanamide inhibits Fas-induced Apoptosis.
    3-Amino-2-piperidinone
  • HY-B1730
    Phensuximide 86-34-0 99.35%
    Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal.
    Phensuximide
  • HY-N0299
    Stachyose hydrate 54261-98-2 ≥98.0%
    Stachyose hydrate is an orally active prebiotic that enhances the growth and activity of beneficial bacteria. Stachyose hydrate has hypoglycemic effects and can improve inflammation by regulating gut microbiota. In addition, Stachyose hydrate can induce plant cell apoptosis (Apoptosis). Stachyose hydrate can be used in research on inflammation, gastrointestinal diseases, and agriculture .
    Stachyose hydrate
  • HY-N0310
    Soyasaponin Bb 51330-27-9 99.13%
    Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities.
    Soyasaponin Bb
  • HY-N0628
    Kaempferitrin 482-38-2 99.94%
    Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.
    Kaempferitrin
  • HY-N2353
    Arabinose 147-81-9 ≥99.0%
    Arabinose is an endogenous metabolite.
    Arabinose
  • HY-N2375
    L-Quebrachitol 642-38-6 ≥98.0%
    L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.
    L-Quebrachitol
  • HY-N6833
    Rebaudioside M 1220616-44-3 99.61%
    Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage .
    Rebaudioside M
  • HY-N7080
    Dihydroferulic acid 1135-23-5
    Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid.
    Dihydroferulic acid
  • HY-P0176
    PACAP (1-27), human, ovine, rat 127317-03-7 99.79%
    PACAP (1-27), human, ovine, rat (PACAP 1-27) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor antagonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively.
    PACAP (1-27), human, ovine, rat
  • HY-P2426
    (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) 118102-98-0 99.45%
    (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.
    (D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
  • HY-P2756
    Alcohol oxidase 9073-63-6
    Alcohol oxidase is a functional enzyme of methanol utilization pathway and can be isolated from yeast peroxisome.
    Alcohol oxidase
  • HY-P3954
    Somatostatin-28 (sheep, human rat mouse) 73032-94-7 99.40%
    Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion.
    Somatostatin-28 (sheep, human rat mouse)
  • HY-Y0504
    Trimethylammonium chloride 593-81-7 ≥98.0%
    Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase.
    Trimethylammonium chloride
  • HY-100277
    Mifobate 76541-72-5 ≥99.0%
    Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects.
    Mifobate
  • HY-103238
    RSVA405 140405-36-3 99.72%
    RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity.
    RSVA405
  • HY-104073
    CAY10602 374922-43-7 98.65%
    CAY10602 is a SIRT1 activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells.
    CAY10602
  • HY-107850
    Pregnanediol 80-92-2 ≥98.0%
    Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo.
    Pregnanediol
Cat. No. Product Name / Synonyms Application Reactivity